Comparative Therapeutic Effects of Alendronate and AIfacalcidol on Cancellous and Cortical Bone Mass and Mechanical Properties in Ovariectomized Osteopenic Rats
نویسنده
چکیده
) Departfnefit oj' St)orLs Medjcirte, Kbio Unjversjty School qJ' Medicine, 3 5 Shinanosnachi, Shinjuku-ku, T!)kyo J60-8>-82, Japan ?H[itnri Co,, Ltd,, Tokyo 1IC]-OO05, kipart ]Dcpartment of Neurology, Mitate HospitaL Fukuoka 826-O041, fapan iPeparttnent (ij' Orthvpaedi(' Su ngeru, l,'ujita iealth b'niversity, Ai('hi 47(F 1 J92, Japan i"ietaholistn Laborcttorg, D(rpartrnent qf TVfedjcjrie, IVinthrop-Universjty Hospital, NY 1 1501,
منابع مشابه
Comparative therapeutic effects of alendronate and alfacalcidol on cancellous and cortical bone mass and mechanical properties in ovariectomized osteopenic rats.
The purpose of the present study was to compare the therapeutic effects of alendronate and alfacalcidol on the cancellous and cortical bone mass and mechanical properties in ovariectomized osteopenic rats in a head-to-head fashion. Twenty-five female Sprague-Dawley rats, 7 mo of age, were randomly divided by the stratified weight method into four groups: the sham-operated control (Sham) group a...
متن کاملComparative effects of alendronate and alfacalcidol on cancellous and cortical bone mass and bone mechanical properties in ovariectomized rats.
The purpose of the present study was to compare the effects of alendronate and alfacalcidol on cancellous and cortical bone mass and bone mechanical properties in ovariectomized rats. Twenty-six female Sprague-Dawley rats, 7 months of age, were randomized by the stratified weight method into four groups: the sham-operated control (Sham) group and the three ovariectomy (OVX) groups, namely, OVX ...
متن کاملEffect of combined treatment with alendronate and calcitriol on femoral neck strength in osteopenic rats
BACKGROUND Hip fracture is associated with pronounced morbidity and excess mortality in elderly women with postmenopausal osteoporosis. Many drugs have been developed to treat osteoporosis and to reduce the risk of osteoporotic fractures. We investigated the effects of combined alendronate and vitamin D3 treatment on bone mass and fracture load at the femoral neck in ovariectomized (OVX) rats, ...
متن کاملEffect of administration of alendronate sodium and retinol on the mechanical properties of the femur in ovariectomized rats.
Alendronate sodium, an aminobisphosphonate with potent antiresorptive activity, is used in the treatment of postmenopausal osteoporosis. Retinol, as a component of multivitamin preparations, is frequently used especially by elderly people. There are no reports on the interaction of alendronate sodium and retinol. The aim of the present study was to investigate the effect of administration of al...
متن کاملTherapeutic effect of risedronate on cancellous and cortical bone in ovariectomized osteopenic rats: a comparison with the effects of alfacalcidol.
The purpose of the present study was to compare the therapeutic effects of risedronate (RIS) and alfacalcidol (ALF) on cancellous and cortical bone in ovariectomized osteopenic rats. Forty-two female Sprague-Dawley rats, 7 months of age, were randomized by the stratified weight method into six groups: the sham-operated control (Sham) group, and five ovariectomized groups: treated with vehicle, ...
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